The artist has given the entirety of his twenty-five thousand pound award prize money to the MVT, which functions to protect the UK's independent music venues.
He was given the award on October 16 as his new release his work was named the outstanding release of the past year.
Fender has opted to hand the money over to the Music Venues Trust, in recognition of the essential function small stages played in his early career.
"I couldn't be pursuing my current career if it weren't for all the performances I played around the area, and elsewhere, when I was starting out," said Fender. "These venues are renowned, but they are struggling."
Beginning in 2023, more than 150 of these spaces have permanently closed – approximately 16% of the entire UK sector.
In the last year, top acts like Pulp, the group Coldplay, the singer Katy Perry and Sheeran have all backed the Music Venues Trust in its attempts to support the industry, by adding a small levy to their ticket costs, which goes to help smaller concert halls.
Sam Fender also took part, collecting more than £100,000 on his recent tour to assist numerous local spots across the UK.
The donation supported locations that were facing potential shutdown due to challenges stemming from floods, fires and family tragedies, as well as regulatory hurdles, court cases and neighbor objections.
Some locations received financial assistance in upgrading facilities and sound and lighting systems that directly benefitted musicians and audiences.
"The concept that funds from concerts in large arenas helps the independent spots, where it all starts for musicians like me, is just common sense," Sam Fender has stated.
The musician is far from the only musician to contribute his Mercury Prize prize money to good deeds.
In they earned the award in the year 1996 for their album Different Class, vocalist Cocker announced that the group would donate their cash to the organization War Child.
That year, rapper and singer she split her prize among a few charities, like the NSPCC and a charity for Sickle Cell.
"Additionally, I gave a thousand pounds to the center, to their classes, because I practiced gymnastics when I was younger and they required better apparatus," Ms Dynamite explained to a publication.
Two years ago, Ezra Collective gave their prize money to the local youth club that developed their group, in addition to other grassroots music organisations.
Also the 1994 recipients M People contributed their prize to a multiple sclerosis charity after a acquaintance was identified with the disease.
"The victory was quite enough," stated vocalist Heather Small. "The prize was the bonus but we didn't need the extra, because we had the main prize. So our victory touched somebody else's life."
Recently, the trust shared it had saved a couple of grassroots venues in that region, by transferring them to public stewardship.
The first in the city and the second in that location were purchased under the Own Our Venues initiative, which is backed by the arts council and music fans who acquire "stakes" in the properties.